Showing posts with label Management. Show all posts
Showing posts with label Management. Show all posts

Monday, 16 September 2013

Test Your CRM Management and Administration IQ

September 16, 2013 09:16 AM ETCIO - The story's as old as system administration: Some parts of the job are straightforward and risk-free, but other tasks are fraught with high error rates and nasty consequences.

Think back to the infamous rm rf * command that erased most of Toy Story 2 before it ever made it out of Pixar. Or go further in time to the Bell Labs study of UNIX users' made mistakes with shell scripts. The vast majority of the mistakes involved the IF statement.

Think things have changed that much with today's all-GUI, all-the-time model of system management?

8 Common CRM Management Issues

I've been tracking the errors my clients and my own people make when managing CRM systems. An amazing number of CRM mistakes fall into just a few categories.

Here they are, in no particular order, along with a set of "IQ test" questions you can ask your team to reduce the likelihood that errors surface in the first place.

How-to: Avoid 3 CRM User Identity Mistakes

The 12 Places CRM Management Issues Appear

Now, where do these issues show up most frequently, and where do they cause the most glaring problems? In amusing places, it turns out:

Teach Your Children Well; Employees, Too

If some of these issues sound familiar, your administrators may need to brush up on Nos. 1 through 3 in the first list. Nos. 4 through 8 are the more interesting problems. Some seem to be only partially "teachable," as they're tightly related to math and logic aptitude. I've seen the same weaknesses show up in Excel formula writing - particularly involving compound Booleans, VLOOKUPs, and pivot tables- so skills in these areas might be improved by taking an advanced Excel course.

Commentary: Why CRM Implementation Needs Training Wheels, Not Racing Gear

If these math and logic skills aren't strong enough in the adult world of sys admins, then what can we tell our kids to do in high school or college? It's not like a trigonometry or chemistry course is going to help much. Probability and statistics? Sure. Accounting, algebra and analysis? Absolutely.

But the core skills are going to be most directly developed in business classes that use spreadsheets and databases extensively. If the courses require the development of macros that teach elements of programming, that's even better. As these classes are available at nominal cost in most community colleges, they're "within reach" for most young adults, even those attending night school.

David Taber is the author of the Prentice Hall book, " Salesforce.com Secrets of Success" and is the CEO of SalesLogistix, a certified Salesforce.com consultancy focused on business process improvement through use of CRM systems. SalesLogistix clients are in North America, Europe, Israel and India. Taber has more than 25 years of experience in high tech, including 10 years at the VP level or above.

Follow everything from CIO.com on Twitter @CIOonline, Facebook, Google + and LinkedIn.

Read more about customer relationship management (crm) in CIO's Customer Relationship Management (CRM) Drilldown.

This story is reprinted from CIO.com, an online resource for information executives. Story Copyright CXO Media Inc., 2012. All rights reserved.

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Saturday, 24 August 2013

10gen CEO: NoSQL has come far, but still needs better security, management

10gen CEO: NoSQL has come far, but still needs better security, management
Credit: iStockPhoto

While NoSQL has made great strides, it will need improvements in multiple areas in order to gain wider acceptance, Max Schireson, the CEO of MongoDB NoSQL database vendor 10gen, said.

NoSQL databases are known for being able to handle great amounts of data that does not necessarily fit well into the relational model, but there is work to be done in areas such as security and manageability in order for NoSQL to gain more adoption, said Schireson at the recent NoSQL Now 2013 conference in San Jose, Calif. "There's lots of work to do before NoSQL as a sector can win."

The NoSQL ecosystem, he said, needs to mature before it can go from a 15- to 20-percent usage level to being used across all organizations with large-scale IT needs. NoSQL needs security improvements like encryption of data and integration with Kerberos and LDAP. It also needs improvements in manageability and integration. Problems like fragmentation and lack of standardization also need to be addressed, Schireson said, noting that NoSQL needs to be made more accessible for users and that it should be easier to do queries and to query different things in new ways.

He also stressed NoSQL vendor priorities, saying that "we need to value user success over short-term monetization." For example, free, open source downloads need to be well-tested and solid. Vendors also must understand what their products can do better than anything else out there and build a product ecosystem, Schireson said.

Improvement already is being seen in the number of persons with NoSQL skills, but it is still a small number, Schireson said. He cited the presence of 50,000 developers with MongoDB skills listed on their LinkedIn accounts. "[The] skill base is growing rapidly." NoSQL already has been embraced by large IT companies like IBM and Microsoft, Schireson noted, further predicting that relational databases will continue to be a big part of the market, but not as dominant as they are today.

This story, "10gen CEO: NoSQL has come far, but still needs better security, management," was originally published at InfoWorld.com. Get the first word on what the important tech news really means with the InfoWorld Tech Watch blog. For the latest developments in business technology news, follow InfoWorld.com on Twitter.


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Wednesday, 21 August 2013

Rackspace hosts VMware management with new dedicated server

The introduction of Rackspace's hosted Dedicated VMware vCenter Server will allow IT staff to control their VMware environments from a data center run by the vendor.

As enterprises move IT infrastructure out of their own data centers, vendors are offering a growing list of alternatives that in Rackspace's world includes hybrid clouds, which combine public and private clouds, and dedicated hosting. The latest addition to the latter offering is Dedicated VMware vCenter Server, which allows IT departments to retain full control with the tools they are used to without having to bother with the underlying infrastructure.

[ Doing server virtualization right is not so simple. InfoWorld's expert contributors show you how to get it right in this 24-page "Server Virtualization Deep Dive" PDF guide. | Track the latest trends in virtualization in InfoWorld's Virtualization Report newsletter. ]

"Many of our customers have large VMware installations in-house today, and they have made significant investments in that and don't want to throw it away," said Andrew Wing, senior product manager at Rackspace.

For companies that want to stick with VMware, but don't want to expand their data centers or have data centers at all, Rackspace already offers managed virtualization based on VMware vSphere 5.1. The addition of vCenter builds on that. From a single console, administrators can control virtual servers running in-house and in Rackspace's data centers. It is also possible to mix vCenter servers that run in an enterprise's own data center and ones that are hosted by Rackspace.

Until now, Rackspace's hosted VMware platform used a shared vCenter model, which only offered limited management capabilities, according to Wing.

Rackspace will at first charge a yet undecided monthly fee per hypervisor that is managed by the hosted vCenter server and in the next phase move to a model where enterprises pay for what they use.

"It is just a question of getting our billing systems set up to make that a reality," Wing said.

Today, enterprises are using Rackspace's managed virtualization to run things like e-commerce platforms and Web content management systems. But Rackspace is hoping to attract more central IT functions, including ERP and CRM systems, according to Wing.

Send news tips and comments to mikael_ricknas@idg.com


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Tuesday, 13 August 2013

WuXi PharmaTech (Cayman) Management Discusses Q2 2013 Results - Earnings Call Transcript

WuXi PharmaTech (Cayman) (WX)

Q2 2013 Earnings Call

August 13, 2013 8:00 am ET

Executives

Ronald Aldridge - Director of Investor Relations

Ge Li - Co-Founder, Chairman, Chief Executive Officer, Member of Compensation Committee and Member of Strategy & Finance Committee

Edward Hu - Chief Financial Officer and Chief Operating Officer

Analysts

David H. Windley - Jefferies LLC, Research Division

Tycho W. Peterson - JP Morgan Chase & Co, Research Division

Wei Du - Goldman Sachs Group Inc., Research Division

Ye Yin - Oppenheimer & Co. Inc., Research Division

John Kreger - William Blair & Company L.L.C., Research Division

Jack Hu - Deutsche Bank AG, Research Division

Iris Wang - Crédit Suisse AG, Research Division

Isabella Zhao - Morgan Stanley, Research Division

Serena Shao - BofA Merrill Lynch, Research Division

Operator

Thank you for standing by, and welcome to the WuXi PharmaTech Second Quarter 2013 Earnings Conference Call. [Operator Instructions] I must advise you that this conference is being recorded today, 13th of August 2013.

I would like to turn the call over to your first speaker today, Ron Aldridge, Director of IR. Please go ahead, Mr. Ron Aldridge.

Ronald Aldridge

Thank you, Derrick, and good morning or good evening to everyone participating in our second quarter 2013 earnings conference call. Hosting this call today is Dr. Ge Li, Chairman and Chief Executive Officer. Joining him is Edward Hu, our Chief Operating Officer and Chief Financial Officer.

During today's presentation and question-and-answer session, we will make forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are not historical facts but instead are predictions about future events. Although we believe that our predictions are reasonable, future events are inherently uncertain, and our forward-looking statements may turn out to be incorrect. Information on many of the risks relating to our forward-looking statements can be found in our filings with the SEC. Our forward-looking statements speak only as of the date on which they are made, and we assume no obligation to update any forward-looking statements, except as required by law.

Also, in discussing our financials, we will use certain non-GAAP measures, which exclude share-based compensation expenses and amortization and deferred tax impact of acquired intangible assets. We believe these non-GAAP operating measures are useful for understanding and assessing underlying business performance and operating trends. Reconciliations of our GAAP to non-GAAP second quarter and first half 2013 results of operations are found in today's earnings release, which has been posted to our website and in the appendix to this presentation. [Operator Instructions]

And now, it's my pleasure to introduce Dr. Ge Li to review our second quarter 2013 performance and to discuss our third quarter and full year 2013 business outlook. Dr. Li?

Ge Li

Thank you, Ron, and good evening or good morning, everyone.

Slide 4 please. I'm happy to report that WuXi had a good second quarter. We had a solid revenue growth of 9.2%. Leading this performance was 18.6% revenue growth in China Lab Services driven by integrated drug discovery and development service and the ramp-up of biologics and the tox services.

U.S. Lab Service had a small year-over-year revenue decline due to a difficult comparison with record revenue in the second quarter of 2012. Manufacturing Service had an excellent quarter. Strong process development and the recent manufacturing revenues largely made up for decline of Commercial Manufacturing revenues year-over-year. We are pleased to see our margins are stabilized. Our gross margins and the operating margin this quarter on both GAAP and non-GAAP basis were comparable to margins during the past year. These stable margins were achieved despite continuing labor inflation, R&D appreciation and the investment in new business.

One important factor for us to achieve stable margins is that we have institute company-wide Lean Sigma programs to improve our operational efficiency, increase productivity and eliminate waste. In addition, business mix is helping as newer business ramp up their revenues and improved their profitability by achieving scale of operations.

We've also had a strong non-operating income in the second quarter, mainly from large mark-to-market gains on foreign exchange forward contracts, which are fairly unpredictable on a quarterly basis, subject to fluctuation of currency exchange rate between the U.S. dollar and RMB.

Foreign exchange gains on forward contracts are intended to partially offset the margin pressure from RMB appreciation. So it is nice that, this quarter, we achieved large foreign exchange gains in a period of time with RMB appreciation, while keeping our margins stable as our hedging strategy worked efficiently and effectively. We also had a relatively low tax rate in the quarter from a one-time tax benefit that we'll discuss later in the presentation.

Due to these factors, we exceeded our revenue guidance for the quarter and have also exceeded our diluted EPS guidance.

Slide 5, please. We will expect continued growth revenue and earnings growth throughout our company. Biologics service and small molecule Manufacturing Service have exciting opportunities ahead of us. Biologics is a unique opportunity for WuXi because of our strong management team, integrated biologics drug discovery development capabilities, state-of-the-art facilities and the regulatory requirements that incentivize companies [indiscernible] Chinese partners if they want to -- speed up developing biologics for the China market.

In small molecule manufacturing, research and manufacturing continued to achieve strong double-digit growth. Commercial manufacturing has turned the corner, with revenue gains from new products, roughly offsetting the revenue loss from single products. And we have now increased our pipeline of Phase III products [indiscernible] to become commercial manufacturing opportunities from the previously announced 7 to 9 products now.

In clinical services, we and our partner PRA took an important step forward this quarter by hiring Dr. James Pusey to be the President and the General Manager of the WuXiPRA joint venture.

As a result of our strong second quarter performance and a good outlook for the second half of 2013, we are increasingly -- we are increasing our full year guidance for both revenue and diluted EPS. We now expect to achieve full year revenues in the range of $572 million to $578 million, full year GAAP EPS of $1.38 to $1.44 and a full year non-GAAP EPS of $1.61 to $1.67.

And now, Ed will discuss our second quarter in more detail. Ed, please.

Edward Hu

Thank you, Dr. Li. Turn to Slide 6, please.

Here you can see our second quarter performance versus our guidance. We exceeded top end of our second revenue guidance by $2.3 million and the top end of diluted EPS guidance by $0.06. Better than expected revenue growth came mainly from biologics, manufacturing and medicinal chemistry business, with most of the rest of the company performing in line with our expectations.

Our better-than-expected EPS growth came from the strong revenue growth in gross[ph] margins and gain from foreign exchange forward contracts and some tax benefit.

Turn to Slide 7, please. Here you can see that our total company revenue growth was driven by China-based Lab Services, particularly from integrated drug discovery and development services and the ramp-up of biologics services and toxicology services. Our Manufacturing Services delivered a strong quarter in the face of a difficult comparison with the second quarter of 2012, which was a record quarter. Strong revenue growth in Process Chemistry and research and manufacturing made up for the decline of Commercial Manufacturing revenue relative to the second quarter of 2012, when commercial products contributed a significant portion of the revenues. Our growing manufacturing product pipeline will drive steady growth in commercial manufacturing revenue in the coming years.

Our U.S.-based Lab Service underperformed this quarter. The lack of large product wins and delay in new project start-up slowed down the revenue growth in the quarter. We expect the second half will be -- will perform better.

Turn to Slide 8, please. Here you can see the quarterly sequence of revenues. We are growing nicely from a trough in last year caused by a slowdown of our Manufacturing Services revenues. China Lab Services continued to have a strong quarter-over-quarter sequential growth, apart from the first quarter, which is typically lower. We expect sequential quarter growth in China Lab Services to continue throughout the year, and we expect a particularly strong fourth quarter based on our conversation with our customers and our business outlook.

U.S. Lab Service revenue has been flat for almost a year due to fewer large project wins, particularly in biologic testing. We expect sequential revenue growth in this business in the second half of the year.

Manufacturing Services revenue has historically been quite lumpy, but we believe this business has achieved the scale that will allow us and our revenue to grow much more steadily going forward as our commercial product portfolio grows.

Turn to Slide 9, please. Looking at our GAAP P&L. We achieved a gross profit increase -- 5% revenue increase as a result of productivity and our operating efficiency improvement that more than offset the labor cost inflation and RMB appreciation.

Operating income grow 8.1%, as we invested in sales and marketing operations and increased R&D expenses to develop new service capabilities. Our 45.5% diluted EPS growth this quarter was due to revenue and profit growth and non-operational incomes. We had $1.6 million of realized gains and $3 million of mark-to-market gains from foreign-exchange forward contracts this quarter. In comparison, in the second quarter of 2012, we had $2.3 million of mark-to-market losses from foreign-exchange forward contracts. The lower effective tax rate in this quarter resulted from full[ph] one-time tax benefit, a $1.1 million refund of 2012 income tax [indiscernible] Chinese legal entities that provides Process Chemistry R&D services, which enjoyed our tax harder year [ph] and a $1.2 million tax benefit from a sup[ph] deduction of R&D expenses that allowed us to deduct 150% of certain 2012 R&D expenses. This is a part of a tax incentive program the Chinese government provides to stimulate companies to invest in R&D and innovate.

Turn to Slide 10, please. Our quarterly GAAP P&L shows record profit, operating income, stable gross margins and operating margin.

On Slide 11, our non-GAAP P&L is similar to GAAP, with about 42% diluted EPS growth for the reasons as we discussed on Slide 9.

Turn to Slide 12, please. Here, we show the quarterly progression. We have achieved record non-GAAP gross profit and operating income with a stable margin trend.

Slide 13, please. So this slide shows that our company revenue base is well balanced and diversified. In addition, these businesses support each other as seamless platform of integrated services from synthetic chemistry at the beginning of a drug discovery program to Phase III clinical testing and commercial manufacturing at any of the drug development. The fastest-growing part of the company is drug development, which has grown from 11% to 16% of the total company revenue in the past 12 months. Medicinal chemistry and other discovery services are also growing about the company average. We will look at each of the business in more detail later in the presentation.

Turn to Slide 14, please. The analysis of year-over-year growth in our second quarter diluted EPS shows somehow the same factors we discussed in the previous quarter. Business growth almost entirely from volume growth is a key driver of our EPS performance and contributed $0.14 to the second quarter 2013 EPS growth.

Mark-to-market gains on foreign exchange forward contracts account for $0.07 of the EPS growth relative to the second quarter of 2012. We had unrealized gains of $3 million in the second quarter of 2013 was unrealized of[ph] $2.3 million in the second quarter of 2012. Other foreign exchange impacts, such as RMB appreciation against the U.S. dollar as well as factors such as labor inflation and investment in new business, continued to have negative impact on EPS.

Turn to Slide 15, please. Our balance sheet remains very strong, with about $300 million cash and about $65 million short-term and long-term bank loans. Our operating cash flow has been strong and steady, with about $40 million cash generated in the second quarter and about $79 million cash generated in the first half of the year. Our capital expenditures have been more variable simply because of timing of purchases. Capital expenditures totaled about $15 million in the first half of 2013, but it will increase considerably in the second half as we have planned. Our full year guidance for total CapEx is still about $60 million.

Turn to Slide 16, please. Our strong second quarter will benefit our full year, and we are increasing our full year 2013 revenue and diluted EPS guidance. We forecast our full year revenue to be in the range of $572 million to $578 million or 14% to 16% year-over-year growth. China Lab Service is expected to grow 16% to 17%. Manufacturing Service, including the ramp-up of biologics manufacturing in the second half of 2013, will grow about 20% to 24%. And U.S. Lab Services will grow low-single digits.

We expect margin trends in the first half of the year to continue in the second half and our guidance to continue to be for full year 2013 gross margin and operating margin, both GAAP and non-GAAP, to be comparable to those in 2012.

And we forecast GAAP EPS in the range of $1.38 to $1.44 or 16% to 21% year-over-year growth and our non-GAAP EPS in the range of $1.61 to $1.67 or 15% to 19% year-over-year growth. Again, we expect the full year CapEx spending to be about $60 million.

Turn to Slide 17, please. I think it's important to take a moment to put this year's performance in context. As you can see from this chart, our strong revenue and diluted EPS growth in 2013 are not one-time events, but a continuation of years of growth built on the historic business model that we are executing successfully, that is building an open-access integrated R&D service platform to serve the global life science industry discover and develop therapeutic products more cost effectively and efficiently.

Turn to Slide 18, please. Here, we give out our preview[ph] for the third quarter. We expect to generate $143 million to $145 million in revenue in the third quarter. And GAAP EPS is expected to be in the range of $0.32 to $0.34, and non-GAAP EPS is expected to be in the range of $0.38 to $0.40.

Now Dr. Li will discuss the performance and strategies in our major business. Dr. Li?

Ge Li

Thank you, Ed. Slide 19, please. Our Synthetic chemistry business continued to achieve single-digit revenue growth from increased volume despite modest pricing pressure and an increasingly competitive environment. Several recent customer wins will drive good sequential growth in the second half of 2013 though[ph] large pharmaceutical companies remain our primary customers, biotech companies are increasingly using our chemistry services.

Despite pricing pressure, we have stable margins in this business, in part, from our new chemistry facility in Wuhan. Wuhan offers a pricing alternative for our customers and now represent about 20% of total synthetic chemistry business. Synthetic chemistry is 1 area where we have been particularly successful in improving our operational efficiency through implementing Six Lean Sigma programs. We have been able to increase the success rate of chemical reactions and reduce material consumption. We are measuring productivity with such metrics as compounds produced per employee and the steps taken to produce compound per employee et cetera in the way we have seen substantial improvement in these areas after training. We think we can maintain single-digit growth in synthetic chemistry beyond 2013.

Slide 20, please. Medicinal chemistry and other discovery services now represent more than 1/4 of the company's revenues and growing at mid-teens rate. We have now 34 lead optimization projects ongoing, mainly with multi-national companies and they are progressing well. We delivered 2 preclinical drug candidates to our customers in the second quarter, and we expect to deliver about 9 additional drug candidates in the second half of this year.

Among other discovery services, biology is growing very rapidly and achieving good customer satisfaction, particularly in support of medicinal chemistry products.

Slide 20 -- 21, please. Despite worldwide toxicology market that has seen little to no growth and the substantial pricing declines in the past 5 years, our tox business is performing very well. It is expected to grow about 40% year-over-year this year and driven by the quality and the value we deliver. Our Suzhou site capacity utilization rate is close to 70% now. Our number of active customers has increased to 48 from 32 a year ago, with healthy mix of large and small Chinese and the multi-national pharmaceutical and biotech companies. About 70% of our studies are now GLP, which speaks to the quality of our services. Many of our studies packages are used by bio clients require R&Ds with the U.S. FDA, European and Australian regulatory agencies, as well as China FDA.

Slide 22, please. Our biologics business performed very well in the second quarter, exceeding our expectation as we gained business from both international and the domestic pharmaceutical companies. We expect revenues to ramp up continuously in the second half of this year and in years to come. With the strong performance, we expect this business to break even probably by the end of this year, about 1 year earlier than our previous expectation. Our project backlog has continued to grow from a $40 million reported last quarter to $53 million now, and we expect further growth in the second half of the year from new contracts. The highlight of the second quarter was our signing an agreement with Ambrx and the Zhejiang Medicine Co. to develop the antibody drug conjugate, ARX788, for treating Her2-positive breast cancer patients.

Other projects are progressing well, such as our joint venture with MedImmune to develop MEDI5117 for rheumatoid arthritis and other autoimmune disorders for the China market. 5 multi-national companies are emerging as our anchor[ph] clients now with the focus of developing innovative biologics products for China market and worldwide. We have completed construction of the drug product fill/finish facility in Wuxi city and is currently being validated. We also have installed 2 2,000-liter bioreactors to produce Phase II and Phase III clinical trial materials starting the second half of this year.

Slide 23, please. Our clinical JV, WuXiPRA, began operation in April and achieved a key milestone with the appointment of Dr. James Pusey as the President and General Manager. Dr. Pusey has 25 year of experience in medicine and the biopharmaceutical industry, including previously served as the founding CEO and President of a major clinical CRO. He also had executive roles at 2 major multi-national pharmaceutical companies, and he was a practicing physician at 4 other hospitals. Under Dr. Pusey's leadership, we expect WuXiPRA to become the clinical service provider of choice in China, a pharmaceutical market that is growing at a mid to high teens annually and will become the second largest in the world within the next few years.

Slide 24, please. Our small molecule manufacturing business was an another source of over performance in the second quarter. Manufacturing service is growing at a high-teens pace this year, driven by our capability in Process Chemistry and the research and manufacturing. We are particularly excited about our growing pipeline of products and the potential products in commercial manufacturing. We are now manufacturing advanced to intermediate for 6 commercial products, 9 Phase III products [indiscernible] could become a long-term commercial manufacturing program for us. 2 of the 9 also particularly have large revenue potential for the company. 3 of commercial -- or Phase III products have been identified by the FDA as breakthrough products, and then a fourth is receiving fast-track FDA review. This again shows the innovative nature of the products that will help our customers to bring to the market.

Slide 25, please. Our U.S. Lab Service business was one of our few areas of disappointment in the second quarter. Revenue were down 3% year-over-year in the second quarter and flat for the first half. A number of factors were responsible: Fewer new business wins, project delays and difficult comparisons with the first half of 2012, when revenue grew 17% on the strength of 2 one-time projects. We expect a low-single digit growth for the full year in the -- however in the longer term, we expect solid growth from the testing business, as the industry is growing pipeline of biologics products, particularly therapeutic antibodies.

Slide 26, please. So to conclude, we outperformed in the second quarter and expect this outperformance to continue throughout the year, which will reflect an increased guidance. Our outperformance was a combination of operational performance, such as higher revenue in biologics and the manufacturing and the cost control and the non-operational items. We believe that all of our business are growth business and that the best future growth opportunities are in integrated drug discovery service, small molecule drug development and manufacturing, biologics service and the clinical services. Again, we're just excited about going to work each day as the knowledge that we're building a broad integrated platform of R&D service have not only provides convenience to our more than 1,000 clients, but also help them realize their dream of being a drug discoverer and developer.

Thank you for your attention. And now, we'll be happy to answer your questions.

Question-and-Answer Session

Operator

[Operator Instructions] Your first question comes from the line of Dave Windley from Jefferies.

David H. Windley - Jefferies LLC, Research Division

I was wanting to dig into customer mix a little bit. You've mentioned in prior quarters some growing demand, growing interest from Chinese domestic customers. And I wondered if you'd comment on maybe where that level is in the company today, how much of your revenue are you deriving from domestic customers and perhaps help us understand which of your business units are seeing most of that demand?

Ge Li

David, thanks for the question. We're seeing continued growth of demand from our domestic customers. But percentage-wise, the revenue is still small. So right now, it's about 5%. And we think, within the next 12 months, it's more likely to grow to 10%.

David H. Windley - Jefferies LLC, Research Division

Okay. And is that in synthetic chemistry, in medicinal chemistry or is it in some of the newer businesses like tox?

Ge Li

Well, actually, across the board, and mostly in medicinal chemistry and the preclinical services.

David H. Windley - Jefferies LLC, Research Division

Okay. And then, a similar question. On biologics, it sounds like you're making really good progress there. Are your customers in biologics a new customer base? Are you essentially cross selling those services into your traditional large pharma core customers?

Ge Li

Actually, both. [indiscernible] increasingly the existing customers and also within new customers.

Edward Hu

Like Ambrx, which is...

David H. Windley - Jefferies LLC, Research Division

I'm sorry. I missed the name there? Like?

Edward Hu

Ambrx.

Operator

Your next question comes from the line of Tycho Peterson from JPMorgan.

Tycho W. Peterson - JP Morgan Chase & Co, Research Division

I wanted to maybe just ask a question on the toxicology business. We've heard from some of the other shareholders[ph] about trends picking up a little bit. Can you maybe just talk about the leading indicators for your tox business to the extent that things are turning a little bit here? Obviously, you've talked about your targets with the new capacity. But can you maybe just talk about whether some of the underlying trends are picking up a bit?

Ge Li

Yes. Tycho, I think that we are steadily growing our tox business as more and more kind of fully integrated R&D packages come into our business. So -- and we have product[ph] good balance of projects from both international clients and the domestic Chinese clients.

Tycho W. Peterson - JP Morgan Chase & Co, Research Division

Okay. I mean, are you able to talk about how, say, like things have trended in the last couple of months? I mean, I think one of your competitors was fairly specific about things picking up in July. And I'm just wondering whether you've seen any sort of near-term inflection here or...

Edward Hu

I don't think there's a huge inflection point yet, but we're seeing a pretty steady growth from both international and domestic customer base.

Tycho W. Peterson - JP Morgan Chase & Co, Research Division

Okay. And then, on Synthetic Chemistry, do you see pricing turning at all? I mean, you talked about it being -- seeing modest declines there. At what point do you think maybe pricing in Synthetic Chemistry starts to stabilize a bit?

Ge Li

I think that we're getting there. So as we indicated, we only saw modest pricing pressure. And also, our Wuhan facility is becoming very productive, and we offer pricing alternatives for our customers.

Tycho W. Peterson - JP Morgan Chase & Co, Research Division

Okay. And then, last one just the outlook for the U.S. lab business. I mean, you commented that was a bit disappointing and has been for a bit. Can you maybe just talk on how you're thinking about that business going forward?

Edward Hu

I think that, in the first half of the year, we have been winning less large projects. I'm not sure whether those similar project has cyclicality, when biochem studies for Phase III programs, $0.5 million each project, and those projects are quite cyclical. But we have clearly a growing pipeline for the second half and into 2014 now.

Operator

Your next question comes from the line of Wei Du from Goldman Sachs.

Wei Du - Goldman Sachs Group Inc., Research Division

Ed, I actually noticed you seem to have some seasonality on the gross margin, especially -- I don't know. I hope my number is right. When I break down the Laboratory Service, often, to show 4Q seemed to be relatively higher. I'm not sure whether that's because random case or it's a trend? I think, second, when I look at the manufacturer service revenue, I think you also -- when we look at your numbers this quarter, it is about 29%. Last quarter, it was 31%. Can we -- This is really a housekeeping item. Can we assume the margin is about that level? Could you give us a little bit more color? I guess especially I want to ask about the biological service, I guess you lumped everything pretty much in the laboratory service in China. And I wonder whether we're seeing the margin improvement, especially sequentially. I think you probably already explained is because the change in service mix. So basically, can I assume the biological service actually offers a relatively higher margin?

Edward Hu

Biologics -- let's step back a little bit. For China Lab Service, actually, the margin typically is highest in the fourth quarter because there were -- the fourth quarter is typically also the highest revenue quarter as many of our customers want to finish their project before the end of the year. So we're always rushing and working very hard to achieve. So historically, we always achieved very strong fourth quarter as the complementing margin also a bit higher than the first 3 quarters. Well, the biologics business, currently still probably runs below the company average and gross margin, but it's ramping up.

Operator

Your next question comes from the line of Ingrid Yin from Oppenheimer.

Ye Yin - Oppenheimer & Co. Inc., Research Division

My question is about the utilization rate of the manufacturing business. Now you have 9 Phase III products in the pipeline. Will you be running into capacity problems at some point next year?

Ge Li

I think our current capacity will support us throughout the next year.

Ye Yin - Oppenheimer & Co. Inc., Research Division

Okay. And then, next year and beyond, you will think about capacity...

Ge Li

Yes, we probably will add capacity, yes.

Ye Yin - Oppenheimer & Co. Inc., Research Division

Okay. Great. And also, if we look at your growth of the 5 different segments, Synthetic Chemistry, which probably has the lowest margin, is going down in terms of percentage of sales; and development is growing at high-double digits. So the service product mix is very favorable for margins. Just wonder if there's potential margin expansion opportunities going forward?

Edward Hu

Ingrid, I think we still are facing the macroeconomics, like the labor cost and RMB appreciation, that trend still stays there. So we are working very hard and through operating improvement and also ramping up the new business and to maintain our margins. I won't be able to comment on the specific sub sector of the margins.

Ye Yin - Oppenheimer & Co. Inc., Research Division

Okay. So can you comment a little on the competitive situation in Synthetic, Medicinal and U.S. Lab and Tox business? I know you don't really have a competitor for the biologics business?

Ge Li

Well, actually, medicinal chemistry and integrated service are our strengths. So we have a very strong management team, and we have a very deep knowledge and understanding of the drug discovery and development. So again, we see consistent wins of discovery products.

Ye Yin - Oppenheimer & Co. Inc., Research Division

Okay. How about Synthetic Chemistry? I mean, are you competing just with local companies, or you're starting to see there are more international players like Indian CROs that are starting to compete for business?

Ge Li

We actually compete globally, and we -- well, in general, our win rate is about 30% of the RFPs for synthetic chemistry. And honestly, with the establishment of the Wuhan facility, our win rate actually is trending up.

Operator

Your next question comes from the line of John Kreger from William Blair.

John Kreger - William Blair & Company L.L.C., Research Division

Do you have any early thoughts that you could pass along on 2014? I'm curious if you got any visibility from your key clients about, kind of, project size and whether or not that could improve revenue growth going into next year? And do you think '14 could perhaps be a year where margins start to improve a bit?

Ge Li

Well, again, we are in constant dialogue with our customers. But it's still too early for 2014. But we do believe the trend now for R&D service outsourcing is now reversed. I think it will continue to grow. So again, actually, we're seeing more and more small individual companies and individuals are using our platform. So it goes with our vision to enable anyone, any company to discover and develop drugs.

Edward Hu

Across our businesses, even though it was showed clearly. But at the trends there, manufacturing business clearly is going to grow. Biologics are ramping up quite nicely, and U.S. operation will improve next year and medicinal chemistry is continuing to grow. So I think in the growth part [ph] you'll see a few impact.

John Kreger - William Blair & Company L.L.C., Research Division

And would you say you're feeling better or worse about the margin outlook given some of the headwinds like wage inflation and currency appreciation?

Edward Hu

It's probably a direction that we're getting better.

Ge Li

Yes. Partially, we don't think RMB will continue to appreciate in the future years. So...

John Kreger - William Blair & Company L.L.C., Research Division

Great. And then, one last question. Could you perhaps elaborate a bit on where you stand with your clinical joint venture with PRA? Are you out competing and signing large clinical programs at this point? Or is that something that you'd be looking to ramp up next year?

Ge Li

Yes. Well, definitely, we look forward to ramping up the business, and we also -- I think with our partners, PRA [indiscernible] aggressively invest in this area, as the China pharmaceutical market continues to grow to mid to high teens. And in the last quarter, we brought Dr. James Pusey on-board. He's a very experienced clinical CRO veteran. So we do believe we have very good chance to become a partner of choice for the clinical service in China.

Operator

Your next question comes from the line of Jack Hu from Deutsche Bank.

Jack Hu - Deutsche Bank AG, Research Division

My question is actually on your Lean Sigma. Can you give us some color what exactly you have done on this initiative and then quantify the impact of margin improvement or margin stabilization? And then, lastly, how sustainable should we expect?

Ge Li

We have across the company-wide Lean Sigma initiatives. So like for example, looking into detail of the process and to improve the efficiency. Again, I -- personally, I do believe that there's always room to improve, so I do feel this is sustainable.

Operator

Our next question comes from the line of Iris Wang from Crédit Suisse.

Iris Wang - Crédit Suisse AG, Research Division

My question was also about the WuXiPRA. So what's your feel about the competition landscape of -- about the clinical services in China because from our perspective we see that increasing number of player are getting into this market. Do you have any concern about the pressure on the pricing? And what is the differentiating factors of the WuXiPRA compared to other clinical service providers in China?

Ge Li

Again, it's not uncommon because to see our competitors in a very high market because for us, I believe the quality of science will differentiate us from others.

Edward Hu

I believe that WuXiPRA is a combined strength of both companies. PRA with the 35 years experience win growth[ph] and WuXi has a strong experience running China operations and also all the laboratory support to focus on[ph] studies.

Iris Wang - Crédit Suisse AG, Research Division

I have a follow-up question on that. I just would like to know more about your advantage[ph] if you have any strengths in the hospital coverage or the any -- cost advantaging the, for example, the monitoring services or the data processing. So what exactly it is?

Ge Li

Again, the market will continue to grow rapidly. And I think we have many clients they want me introduce their products for China. So again, clinical business requires a very high level of confidence, credibility and trust. I think, as Ed just mentioned, with 35 years of experience -- clinical experience -- global experience of PRA and 13 plus years of China operation -- CRO experience of WuXi, we do believe that we have a good advantage. So again, I think WuXiPRA is aiming to offer global-standard, high-quality CRO clinical service in China.

Operator

Your next question comes from the line of Bin Li from Morgan Stanley.

Isabella Zhao - Morgan Stanley, Research Division

And I'm Isabella asking questions in behalf of Bin Li. Actually, most of my questions has been answered. I just want to follow up with WuXiPRA. What's your sales revenue outlook for the -- for this JV, and when are we going to see any top line contribution from this JV?

Edward Hu

Actually, the WuXiPRA -- it will be a separate company. So the SG&A won't be consolidated into WuXi's P&L. So it's reported as equity income or loss line in our P&L. So going forward, we won't be able to disclose the revenues of WuXiPRA. But arguably, right now, the joint venture is just up and running. It probably would take some time to ramp up. And particularly, at the larger clinical studies, if we'd win the project today, it will take 6 to 12 months to get started because clinical trial approval process in China is very long. But it has a great pipeline ahead starting from next year.

Isabella Zhao - Morgan Stanley, Research Division

And also, 1 last housekeeping question. For the foreign exchange forward contracts gain, are we going to expect any more gains in the second half?

Edward Hu

We're continuing going to see gains -- realized gains of the forward-exchange contracts because those contracts will enter into last year it's all[ph] the money. Unrealized gains are also subject to the exchange rates at quarter end when we close the quarter. So if the RMB stops to appreciate and then we probably won't expect to see any mark-to-market gain or losses. If RMB continue to appreciate, then we'll continually going to see mark-to-market gains.

Operator

Your next question comes from the line of Serena Shao from Bank of America.

Serena Shao - BofA Merrill Lynch, Research Division

Actually, most of my questions have been answered. I just have a very quick question on your toxicity capacity utilization. How -- what percentage of the current capacity has been utilized?

Edward Hu

Actually, we talked about it in the slide. Currently, our total toxicology facility utilization is around 70%.

Operator

[Operator Instructions] Our next question comes from the line of Dave Windley from Jefferies.

David H. Windley - Jefferies LLC, Research Division

I wanted to ask about CapEx. There was an earlier question about manufacturing capacity, I believe. And I guess I'm just curious more broadly across the business, as you look beyond 2013, do you believe your CapEx levels are sustainable at the current level? Or would you expect any, kind of, step-function increases in CapEx for buildings or other capacity?

Ge Li

David, we do expect the CapEx around the current level with some fluctuations. I will say, aggressively, we probably will go around like $70 million to $75 million, but not really more than that.

David H. Windley - Jefferies LLC, Research Division

Okay. That's helpful. And then, your slides mentioned, 2 -- I think there were 2,000 liter bioreactors that you've added in the biologics manufacturing. And I wondered if those were installed specifically for 1 client or compound in particular, or are you just putting in general capacity to be sold to multiple clients for culturing?

Edward Hu

Yes. Those bioreactors are actually going to be used -- can be used for manufacturer most of[indiscernible] anybody products. But we have -- we do have 1 kind in mind, we need to start a manufacture for the Phase II, Phase III clinical supply starting in the second half of this year. This is a pretty significant campaign [indiscernible] better but the facility itself is actually multifunctional and can be used for any products.

David H. Windley - Jefferies LLC, Research Division

Okay. And I believe you said those are in validation. So everything is on track to start this [indiscernible] campaign for this client and the revenue from that is included in your guidance for the second half. Is that correct?

Edward Hu

Yes.

Operator

[Operator Instructions]

Edward Hu

Operator, we probably can conclude this conference call.

Operator

There are no further questions at this time. I will now hand the call over to the speaker.

Ronald Aldridge

We'd like to thank you very much for calling in, and we appreciate your attention and your thoughtful questions. We look forward to speaking to you again in November to go over our third quarter results. Thanks very much.

Ge Li

Thank you.

Edward Hu

Thank you.

Operator

That does conclude our conference for today. Thank you for participating. You may all disconnect.

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Alimera Sciences Management Discusses Q2 2013 Results - Earnings Call Transcript

Alimera Sciences Inc (ALIM): Alimera Sciences Management Discusses Q2 2013 Results - Earnings Call Transcript - Seeking Alpha (function(_,e,rr,s){_errs=[s];var c=_.onerror;_.onerror=function(){var a=arguments;_errs.push(a); c&&c.apply(this,a)};var b=function(){var c=e.createElement(rr),b=e.getElementsByTagName(rr)[0]; c.src="//beacon.errorception.com/"+s+".js";c.async=!0;b.parentNode.insertBefore(c,b)}; _.addEventListener?_.addEventListener("load",b,!1):_.attachEvent("onload",b)}) (window,document,"script","4ffae9d6f05d1da630000008"); if (SA.Data && SA.Data.Cache) { var adata = SA.Data.Cache.get('campaign_content'); }.market_currents_list li .ticker_date_left .mc_list_tickers a{font-weight: normal} var ms_slug = ''; var article_dashboards = 'transcript'; var article_sectors_themes = '@transcripts@us@drug-manufacturers-major@healthcare@article@'; var ratings_hash={} var ARTICLE_ID = 1630202 ; var ARTICLE_TYPE = 'transcript'; var ARTICLE_LOCK = ""; var availableABVersions=["ver_a"]; var abOBJ = new ABTest('transcript_pagination', availableABVersions); var machine_id = cookieExists('machine_cookie') ? parseInt(readCookie('machine_cookie')) : 0; var abVersion = abOBJ.value; var sliceSize = 4000; try {window.sessionStorage.setItem("/article/"+ARTICLE_ID, '1');} catch (error) {}var mone_article_tags = "{alim};;;{healthcare};;;{transcripts,us,drug-manufacturers-major};;;{}"var ord = Math.floor(Math.random()*1000000000);Seeking Alpha Seeking Alpha Portfolio App for iPad Finance (1) var ipadData; SeekingAlpha.Initializer.AddAfterLoad(function(){ if (SA.Utils.Env.isIPad && !/3/.test(SA.Data.Cookies.get("user_devices"))){ Mone.event("ipad_promotion_top","top_ipad_banner_large","ipad_promotion_displayed"); ipadData = new SA.Data.iPad(); ipadData.instanceName = "ipadData"; var responseHandler = new Object(); responseHandler.handleResponse = function(data){ if (!data.averageUserRating) return; var stars = data.averageUserRating Home | Portfolio | Market Currents | Investing Ideas | Dividends & Income | ETFs | Macro View | ALERTS | PRO   This transcript was sent to 446 people who get email alerts on  . Which cover: new articles | breaking news | earnings results | dividend announcements Get email alerts on   » This transcript was sent to   people who get the newsletter. Get the newsletter » Comments () This article has  comments. To read them or add your own, click here. Download the Free Seeking Alpha Portfolio App Now! The #1 Portfolio App is Now on iPad! Get instant notifications & never miss a critical update on your stocks! Which Seeking Alpha App is best for you? Seeking Alpha Portfolio Tech Investor ETF investor Energy Investor Email me a link to open from my phone: Continue Alimera Sciences Management Discusses Q2 2013 Results - Earnings Call Transcript Aug 12 2013, 18:10  |  about: ALIM if (getURLParam('source') == 'yahoo'){ $('yahoo_finance_link_container').innerHTML = 'back to yahoo finance'; }

Executives

Richard S. Eiswirth - Chief Financial Officer, Principal Accounting Officer, Chief Operating Officer, Vice President, Treasurer and Secretary

Charles Daniel Myers - Co-Founder, Chief Executive Officer, President and Director

Analysts

Adam Darity

Simos Simeonidis - Cowen and Company, LLC, Research Division

Alimera Sciences (ALIM) Q2 2013 Earnings Call August 12, 2013 4:30 PM ET

Operator

Good day, ladies and gentlemen, and welcome to the Alimera Sciences Second Quarter 2013 Earnings Conference Call. [Operator Instructions] As a reminder, this conference call is being recorded. I would now like to turn the call over to Rick Eiswirth. You may begin.

Richard S. Eiswirth

Thank you. Good afternoon, everyone, and welcome to the Alimera Sciences conference call to update you on our commercialization of ILUVIEN in Europe, and to review our second quarter financial results. A press release regarding these results was issued this afternoon and is available on our website. On the call with me today is Dan Myers, our President and Chief Executive Officer.

Before we begin our prepared remarks, I would like to remind you that various statements we make during this call about the company's future results of operations and financial position, business strategy and plans and objectives for Alimera's future operations are considered forward-looking statements within the meaning of the Federal Securities Laws. Our forward-looking statements are based upon current expectations that involve risks, changes and circumstances, assumptions and uncertainties. These risks are described in the Risk Factors and management's discussion and analysis of financial condition and results of operations sections of Alimera's annual report on Form 10-K for the fiscal year ended December 31, 2012, which is on file with the SEC and available on the SEC's and Alimera's websites.

Additional factors may also be set forth in those sections of our quarterly report on Form 10-Q for the quarter ended June 30, 2013, to be filed with the SEC in the third quarter of 2013. We encourage all investors to read these reports and our other SEC filings.

All of the information we provide on this call is provided only as of today, and we undertake no obligation to update any forward-looking statements we may make on this call or on account of new information, future events or otherwise. Please be advised that today's call is being recorded and webcast.

Additionally, adjusted net loss and adjusted net loss per common share, non-GAAP financial measures, will be discussed on this conference call. A reconciliation to the most directly comparable GAAP financial measures can be found in our press release, which is available on the SEC's and Alimera's websites.

And with that, I would like to turn the call over to Dan Myers, our President and Chief Executive Officer. Dan?

Charles Daniel Myers

Thanks, Rick. We are very pleased we've begun generating revenue from ILUVIEN sales in Germany and U.K. in the second quarter of 2013. Today, ILUVIEN has been used by 14 physicians in the U.K. and Germany to treat 30 patients suffering from the effects of chronic diabetic macular edema. As you may recall, one of the key outcomes from the FAME study was identifying the subpopulation of chronic DME patients. Patients with a shorter duration of disease, non-chronic if you will, responded as well to available therapies as they did to ILUVIEN. But with the chronic or longer duration disease patient, visual acuity response to ILUVIEN was significantly better during the FAME Study, indicating that these chronic patients were insufficiently responsive to available therapies and therefore had very limited options for treatment.

The initial response has been very positive among the early adopting physicians, as well as patients, with reports of important improvements in visual acuity. As a result of the early success, some patients have even been treated with ILUVIEN in their second eye. A specific example comes from Dr. Albert Augustin, head of the Department of Ophthalmology at the City Hospital in Karlsruhe, Germany, where a 68-year-old pseudophakic patient with macular edema, which was unresponsive to repeated anti-VEGF steroid injections, showed an impressive anatomic improvement after an ILUVIEN injection in both eyes. The patient gained 2 lines of best corrected visual activity in both eyes over a 4-week period after the injection of ILUVIEN. The patient also tolerated the medication well and did not develop an increase in intraocular pressure. Physicians are seeing firsthand the potential benefit to patients using ILUVIEN.

It's important to consider the ILUVIEN uptake to date, in light of the market access environment currently in Europe and the hurdles this presents in patient acquisition of ILUVIEN, our teams have been working to overcome these since the initial commercial trial, but history tells us this can take some time.

The situation in the United Kingdom to date has been greatly affected by the National Institute for Health and Care Excellence or NICE, and their final appraisal determination in January to not recommend ILUVIEN for our labeled indication. However, as we announced in June, NICE's Appraisal Committee has issued a positive Appraisal Consultation Document or ACD recommending ILUVIEN for the treatment of pseudophakic patients with chronic DME considered insufficiently responsive to available therapies. We are hopeful that the ACD, which the Appraisal Committee is expected to discuss later this month, will lead to a new Final Appraisal Determination or FAD in early September, confirming the recommendation in the ACD.

We believe the implementation of the guidance, if published, will be supported by the National Health Service, resulting in adoption and uptake beginning as early as fourth quarter of 2013.

In Germany, the challenge is more complex, involving individual negotiations with 2 dozen key statutory health insurers and associations to secure reimbursement agreements for patients. Until these agreements are in place, patients in Germany are required to seek reimbursement through an individual funding request. The resulting administrative birth can take a number of weeks to conclude, and we believe this is partly responsible for the slow commercial adoption of ILUVIEN in Germany.

Today, the number of individual funding request under consideration for reimbursement in Germany is more than 3x the number of patients who've actually received ILUVIEN.

We believe our preparation for commercial launch in France is progressing well. As we announced last month, the Transparency Commission of the French National Health Authority issued a favorable opinion for the reimbursement and hospital listing of ILUVIEN by the French National Health Insurance.

We are pleased with the comparative clinical benefit rating we received, as only 11.6% of all new products under CT initial review in 2013 received this level or better. Additionally, we anticipate that patients will be reimbursed for 100% of the cost of ILUVIEN as part of the specific program for chronic diseases.

This opinion is expected to provide support in our pricing negotiations and discussions in the coming weeks. We anticipate this negotiations to take approximately 3 months, which could allow for the commercial launch of ILUVIEN in France in early 2014.

We continue to work on pricing and reimbursement in Italy, Spain, Portugal and Austria, but do not currently plan to commercialize ILUVIEN in those countries until we achieve positive cash flow and sustainability in Germany, the United Kingdom and France.

In conclusion, while the second quarter ILUVIEN sales were modest, we believe that we understand the reimbursement hurdles and are making progress in the U.K., and are aggressively pursuing reimbursement in Germany. Our sales teams continue to educate physicians and their staff on the insufficiently responsive patient, where ILUVIEN's benefits of efficacy and long-term drug delivery can provide new hope. We believe that ILUVIEN has positioned to assist the large and growing patient population in need.

Now I'll turn the call back over to Rick to briefly discuss our first quarter financials.

Richard S. Eiswirth

Thank you, Dan. Turning to our financial results for the second quarter of 2013, we began generating revenue from ILUVIEN totaling $179,000 on the sale of 18 units. Net loss attributed to common shareholders for the quarter ended June 30, 2013, was $21.3 million or $0.67 per common share, compared with net loss attributed to common shareholders of $4.7 million or $0.15 per common share for the quarter ended June 30, 2012. Net loss attributable to common shareholders for the quarter ended June 30, 2013, was impacted by a noncash warrant valuation adjustment of $6.7 million, resulting from the increase in our common stock price, noncash accretion of a beneficial conversion feature of $5 million associated with the decrease in the conversion price of our Series A Convertible Preferred Stock, and a loss of $153,000 related to the early extinguishment of debt.

On June 30, 2013, the conversion price of our Series A Convertible Preferred Stock was adjusted to $2.66 per share of common stock because we have not received final positive guidance from NICE regarding the reimbursement of ILUVIEN in the U.K. as of that date. Adjusted net loss attributed to common shareholders, a non-GAAP measure that excludes the noncash warrant valuation adjustment, the accretion of the beneficial conversion feature and the loss on early extinguishment of debt, was $9.5 million or $0.30 per common share for the quarter ended June 30, 2013, compared to $4.7 million or $0.15 cents per common share for the quarter ended June 30, 2012.

Research and development expenses for the second quarter of 2013 increased to $2.2 million compared to $1.9 million for the second quarter of 2012. The increase was primarily attributable to approximately $240,000 in costs associated with contracting medical science liaisons to engage with retina specialists in the study of ILUVIEN in Germany and the U.K. and in France.

General and administrative expenses in the second quarter of 2013 were $2.4 million compared to $1.5 million in the second quarter of 2012. The increase was primarily attributable to an increase in our professional fees associated with the establishment of our infrastructure and tax planning for expansion in Europe.

Sales and marketing expenses in the second quarter of 2013 increased, as expected, to $4.9 million, compared to $1.1 million for the second quarter of 2012. The increase was primarily due to increased costs associated with contracting with Quintiles Commercial for services in connection with our launch of ILUVIEN in Germany and in the U.K. during the second quarter of 2013.

We expect continued increases in sales and marketing expenses as we continue to execute on our plans for ILUVIEN's commercialization in the EU.

As of June 30, 2013, we had cash, cash equivalents and investments of $31.9 million compared to $49.5 million as of December 31, 2012. In May 2013, our U.K. subsidiary entered into a loan and security agreement with Silicon Valley Bank to provide additional working capital in the amount of $5 million, and up to an additional $15 million under working capital line of credit. The line of credit will be utilized to finance eligible accounts receivable in the U.K., Germany and France, and replaces the $20 million line of credit previously provided by Silicon Valley Bank to finance accounts receivable in the U.S.

The debt facility provides us with additional resources as we work to strengthen our market position of ILUVIEN in Europe. Currently, we have no outstanding borrowings on the line of credit.

Now I'll turn the call back over to Dan for closing comments.

Charles Daniel Myers

Thanks, Rick. We're very pleased to be seeing the physicians and patients benefit from injections of ILUVIEN in the U.K. and Germany. As you know, we've worked hard over the past several years to make this a reality and our people are committed to ensuring that many more long-standing chronic DME patients can experience the potential benefits of ILUVIEN in these countries and future markets.

Now with regards to the FDA, before we head into the Q&A session of this call, I want to remind everyone that we do not have any material updates at this time. We currently have had our standard mid-cycle review with the FDA, but as you know, we are not in position to comment on that meeting. We look forward to updating you on the status of our October 17 PDUFA date of our NDA for ILUVIEN.

I will now turn it back over to the operator for any potential questions.

Question-and-Answer Session

Operator

[Operator Instructions] The first question is from Amit Bhalla of Citi.

Adam Darity

This is Adam in for Amit today. I just wanted to clarify one point to, I think Dan have said initially that 30 patients have been treated, and then, Rick, I believe you said that 18 units have been implanted. Can you help me reconcile those 2 numbers?

Richard S. Eiswirth

Yes, certainly. The number of patients and physicians that experienced ILUVIEN that didn't quit at the beginning were as of today versus the 18 units that we referenced were actually the sales in the second quarter.

Adam Darity

Okay. All right. That makes sense. Okay. And then, maybe could you comment on how many patients had multiple eyes done, or had both eyes done?

Charles Daniel Myers

Adam, I can't comment on them, it's been anecdotal to the clinical account specialist. I do know of 3. It's been 3 to 4. So call it at this point maybe 10%. That would be an estimation.

Adam Darity

Okay. And then, maybe you can help, what are the expectations for the rest of this year and maybe as we look into 2014, on the number of physicians that you're targeting and expect to be in contact with and have prescribing ILUVIEN, as well as the number of centers that you're hoping to be into by the end of this year?

Charles Daniel Myers

I don't have right in front of me the exact number of hospitals or clinics or individual physicians. I can tell you that in our mapping of our territories and mapping of our CAS in those 3 countries, we have coverage with approximately -- we're still finalizing between 16 and 17 CAS, or sales representatives is how you want to call it, that we will cover 100% of the centers that do implants either through a hospital setting, clinics or private settings. I would not address right now the number of accounts per rep. I did not have that in front of me.

Adam Darity

Okay. And then, maybe you can talk a little bit about the expectations for the product launch, I mean, it sounds like everything is positive so far, it's just reimbursements been a little slow to trickle in. What are your expectations this quarter and as we look through the rest of this year for the actual trajectory?

Charles Daniel Myers

Well, I think, what you said is accurate. I think, the reimbursement and market access has been, as I said in my earlier comments, one of the biggest impediments. I think, we can say that physicians that have implanted, and I have had a chance to talk to personally a few of them, there's also have been good in what we would like to see. I also think we've been fortunate that early on, the physicians understand the patients that we should be using ILUVIEN on. As you know, in any launch, it's really key that the doctors don't basically try your product on just any patient because it's new product and I want to just get an experience with it. It's very important with our indication that the doctor use the product on label. And I think, early on, identifying these patients and knowing what kind of patient ILUVIEN works best on has been a real positive because we have had very good outcomes in the early limited early adoption. But clearly, as we've said in our early comments, the uptake has been a little slower than we expected primarily because of market access and those hurdles. So I think, the key is going to be more the fourth quarter and the exit ramp that we come out of. And so I think you'll see still a little bit of a flattening of the uptake for the next few months as we work through not so much the demand creation, but the access to the product, and hopefully, that will show us what -- we could be that dreaded hockey stick I know people hate to see. But I think, more importantly, would be the fourth quarter, how we exit the year, because we hope to have most of these reimbursement and market access hurdles behind us by the time we exit the year and get a start on 2014.

Adam Darity

Okay. And then, just one last one. On the KKs in Germany, how penetrated are you so far with some of the reimbursement and contracts there? Are you still on target to hit about 60% in 3Q?

Charles Daniel Myers

Yes. Towards the end, it depends on what -- if you talk about on a finalize contract, I mean, some of these, as you know, the contract, it gets down to a lot of granular work towards the end. I can tell you this, so far, we had interaction and are currently working with KKs that represent about 43% of the market. So -- now that's not suggesting they're all contracted yet, but we're in meetings and active work with 43% at this stage. We've been in touch or at least made contact in the process of scheduling an appointment, which would account for about 90% of the market, so we're actively engaged with the right key accounts, we're actually kind of in the midst of discussions with about 43% of the coverage and have reached out to that 90% of the coverage.

Operator

The next question is from Simos Simeonidis of Cowen and Company.

Simos Simeonidis - Cowen and Company, LLC, Research Division

Can you tell us from the 18 units that were sold in the first quarter, how many were in the U.K. and how many in Germany?

Richard S. Eiswirth

About 90% of those were in Germany at this time.

Simos Simeonidis - Cowen and Company, LLC, Research Division

90% was in -- Okay. And then, for the 30 patients that have been treated so far as of today, is it pretty much the majority still in Germany?

Richard S. Eiswirth

Yes, that's correct. The majority is occurring in Germany because we've been able to facilitate the reimbursement there through the KKs. However, as Dan mentioned earlier, we continue to have challenges with NICE, the NICE process dragging out the reimbursement in the U.K.

Charles Daniel Myers

And Simos, let me elaborate on it just for a moment, it's kind of a double-edged sword, and of course, you know very well the NICE process from prior history. The good news is when we got the ACD sort of reversal, if you will, with the anticipation of the positive final termination in September, what we found and a little bit of an unfortunate position, is doctors who had patients they might have implanted during the summer, if in fact they know the NICE and National Health Services is going to pay for this in the coming months, in a few cases, decided they're going to wait and let their patients determine if they're eligible for coverage versus private pay. Obviously, a patient who is not a pseudophakic patient will still be a private pay, but if you're a pseudophake, then there are some doctors who unfortunately are waiting to see how the NICE reimbursement will go because, clearly, that will be to the benefit of the patient. So it's a little bit of a double-edged sword on this NICE approval.

Simos Simeonidis - Cowen and Company, LLC, Research Division

Right. That makes sense. You talked about spending the little bit, how should we think about it going forward for the next 2 quarters? I mean, should we expect a slight increase as you're ramping up your efforts in Europe or would you spend the first half of the year would be a good proxy for 3Q or in 4Q?

Richard S. Eiswirth

You will continue to see some increases in the sales and marketing expenses over the latter half of the year as we ramp up and prepare for the launch in France, and deploy the full sales team in the U.K. on, hopefully, completion of the NICE guidance.

Simos Simeonidis - Cowen and Company, LLC, Research Division

Okay. Great. And finally, Dan, I know you can't talk about the FDA because you're a few weeks away, 2 months away, but is there any more meetings that are supposed to happen between now and then, I assume there are?

Charles Daniel Myers

Yes. I can comment on that. We did have the mid-cycle review meeting, and the FDA, at that meeting, did assure us that they would been in continued dialogue, if we had follow-up questions and other issues to clarify. The minutes of that meeting are just now being submitted, it took place just a little over a week ago. And so, until we get agreement on the meeting minutes so we can all agree what was said and wasn't said there, the course forward is of course when we would ask for another meeting or clarification would be determined in the coming weeks.

Operator

[Operator Instructions] There are no further questions at this time. I'll turn the call back over to Dan Myers for closing remarks.

Charles Daniel Myers

Thank you for listening to today's call. We look forward to updating you on our progress in the coming months. And operator, we will now conclude this call.

Operator

Thank you. Ladies and gentlemen, this concludes today's program. You may now disconnect. Good day.

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Saturday, 10 August 2013

PAREXEL International Management Discusses Q4 2013 Results - Earnings Call Transcript

Executives

Jill Baker - Corporate Vice President of Investor Relation

Josef H. Von Rickenbach - Founder, Chairman and Chief Executive Officer

James F. Winschel - Chief Financial Officer, Principal Accounting Officer, Senior Vice President and Treasurer

Analysts

Timothy C. Evans - Wells Fargo Securities, LLC, Research Division

Douglas D. Tsao - Barclays Capital, Research Division

Robert P. Jones - Goldman Sachs Group Inc., Research Division

David H. Windley - Jefferies LLC, Research Division

Evan A. Stover - Robert W. Baird & Co. Incorporated, Research Division

Todd Van Fleet - First Analysis Securities Corporation, Research Division

Roberto Fatta

Gregory T. Bolan - Sterne Agee & Leach Inc., Research Division

PAREXEL International (PRXL) Q4 2013 Earnings Call August 8, 2013 10:00 AM ET

Operator

Good day, ladies and gentlemen, and welcome to the PAREXEL International Fourth Quarter and Fiscal Year 2013 Earnings Call. [Operator Instructions] I would like to hand the conference over to Jill Baker, Corporate Vice President of Investor Relations. Ma'am, please go ahead.

Jill Baker

Good morning, everyone. The purpose of this call is to review the financial results for PAREXEL's fourth quarter and fiscal year 2013. With me on the call in the room today is Josef Von Rickenbach, our Chairman and Chief Executive Officer; and James Winschel, Senior Vice President and Chief Financial Officer. Ingo Bank, who will be formally assuming CFO responsibilities on September 1 is also on the call, but he will not be a speaker today. He looks forward to speaking with you on the first quarter earnings call on October and to meeting with investors as we go forward.

We would like to begin by stating our standard Safe Harbor disclosure language. Various remarks that we may make about future expectations, plans and prospects for the company constitute forward-looking statements for purposes of the Safe Harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors. These factors are discussed in the Risk Factors section of the company's 10-Q report as filed with the Securities and Exchange Commission on May 6, 2013, and in our earnings press release issued yesterday.

In addition, any forward-looking statements represent our views only as of today and should not be relied upon as representing our views as of any subsequent date. While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so even if our estimates change. Therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.

During this call, we will refer to certain financial measures, which have not been prepared in accordance with Generally Accepted Accounting Principles. When discussing numbers or margins related to revenue, selling, general and administrative expenses, income from operations, income taxes, net income and earnings per share, we may refer to adjusted results.

These adjusted results may exclude the impact of unusual positive or negative items, including those related to foreign exchange, special charges, tax items and restructuring reserves and adjustments to those reserves. In each instance, a reconciliation of the non-GAAP financial measures with the most directly comparable GAAP measures may be found in the press release, in the Additional Financials portion of the Investor Relations section of our website, or will be discussed during the course of this teleconference.

[Operator Instructions] I would now like to turn the call over to Mr. Von Rickenbach.

Josef H. Von Rickenbach

Thank you, Jill, and good morning, everyone. I'd like to start today by providing some commentary on our results for the fourth quarter and the fiscal year and then discuss our outlook for fiscal year 2014. Following that, Jim will provide more detailed information on the financials, and we will then open the call to questions.

Before I dive in, I'd like to pause a moment to thank Jim for his hard work over the past 13 years. He's done a great job for the company and has made many valuable contributions that have helped PAREXEL to grow and retain its role as a leader in the CRO industry. During Jim's tenure, the company's service revenue increased by $1.4 billion, backlog grew by over $4 billion and there has been an increase in the market capitalization of the company from $225 million to almost $3 billion.

On a personal note, I'd like to thank him for his leadership and counsel over the years. As you know, Jim will be moving on soon to the position of Executive Vice President and plans to retire in June 2014. I look forward to continuing to work with him in the interim.

Fiscal year 2013 was a very productive and successful year for the company. Many of our plans and investments came to fruition and our progress was well received by the market. We delivered strong growth in revenue and earnings per share and achieved an operating margin of 8%, up 120 basis points over fiscal year 2012. I'm very pleased with the progress we made in our business units and believe that we are well positioned for additional growth and improvements as we start a new fiscal year.

Speaking now to the results of the fourth quarter. Service revenue was $463.1 million compared with $392.6 million in the same quarter of the prior year, an increase of 18%. Excluding the negative impact from foreign exchange movements of $2.6 million in the current quarter, revenue increased 18.6%. Recent acquisitions contributed $12.7 million in revenue to the quarter's results. And on a same-store basis, revenue increased by 14.7%. On a constant currency, same-store basis, revenue increased 15.4% year-over-year. For the entire fiscal year, revenue was approximately $1.7 billion compared with $1.4 billion in fiscal year 2012, a year-over-year increase of 24%. Foreign exchange and M&A activities had a minimum impact on the growth rate.

With regard to client concentration, the largest client in the June quarter represented 17% of revenue as compared to 11% in the fourth quarter, 1 year ago. The top 5 clients represented 49% versus 45% and the top 20 clients were 80% as compared to 74%. For the full fiscal year, the top client was 17% of service revenue, up from 9% in fiscal year 2012. The top 5 represented 50%, up from 40% a year ago and the top 20 comprised 79% of the total as compared with 74%, 1 year ago.

As you may recall, given the increasing level of client concentration, which became evident 1 year ago, we intensified our efforts to further diversify our client base. We created our BioPharm unit, which focuses on meeting the needs of small and midsized clients. The amount of work that we have won from large biopharma companies in Strategic Partnerships continues to impact the client concentration numbers. However, we are pleased with the results of our diversification efforts with respect to small and midsized clients, and expect to remain competitive in this area of the market.

During the fourth quarter, Clinical Research Services or CRS, represented 74% of the company's total revenue, which was the same as in the prior year. PAREXEL Consulting and Medical Communication Services or PCMS, comprised 12% as compared to 13%, 1 year ago and Perceptive Informatics was approximately 14% of the total versus 13%, 1 year ago. The result for the full year had a similar split.

Now I'd like to make some comments about each of our businesses. In our CRS segment, gross margin in the fourth quarter improved 3.6 points year-over-year. Part of the improvement was achieved by continuing to replace high-cost contractors. We expect to achieve more progress in this regard and to reach our sustainable target by the end of the current calendar year. We also expect to see the continued benefits of ongoing improvement initiatives reflected in the CRS gross margin in the first quarter and beyond.

There are other opportunities for margin improvement for the business. For example, we are enhancing our resource allocations to improve project utilization. We are simplifying our processes with the goal to have fewer handoffs in order to improve productivity. And another initiative is focused on adding staff to lower-cost countries as appropriate.

On the recruitment, hiring and training front, we are now moving into a more steady-state mode. As our revenue growth rate normalizes, we expect the rate of hiring to decrease in fiscal year 2014, and for utilization to improve.

Moving to PCMS, the business had an outstanding year of progress and success with organic revenue growth of approximately 20% while maintaining a gross margin above 40%. We are continuing to identify new revenue growth opportunities for PCMS while maintaining our focus on profitability. The business had a leadership change during the fiscal year and we implemented our internal succession plan smoothly. The business is currently focused on integrating the acquisition of HERON and on deriving synergies by cross-selling services with recently acquired Liquent.

In Perceptive Informatics, our long-term strategy to provide a robust platform of technology products and services to our clients has continued to pay off. Under the new leadership, we have tightened the organizational structure and positioned the business more optimally for the future. Increasingly, technology is becoming a more integral part of clinical research and the tie-in with CRS is becoming closer. We will continue to ensure that we are deriving the highest possible value from our substantial investments in technology across the entire company. With regard to Liquent, results are ahead of our expectations thus far, and integration activities have progressed according to plan.

Moving on to new business dynamics. Backlog of $4.6 billion at the end of the fourth quarter was up 4.9% year-over-year and up 2.3% sequentially. The impact from foreign exchange was nominal in the quarter.

The majority of our business wins continue to be from Strategic Partnerships, but we did achieve solid double-digit growth in gross new business awards from the small and emerging Biopharma company segment, compared with the fourth quarter of last year. We continue to be pleased with our win rate.

The level of our pending proposals at the end of the quarter was up compared to a year ago, indicating that there continues to be a good amount of opportunity in the marketplace. We also received a healthy flow of new requests for proposals during the quarter.

Cancellations came in at 4.6% of the beginning backlog within our expected range. For the fiscal year overall, the quarterly average cancellation rate was just under 5%, which was at the high end of the expected range. The main reason for cancellations continues to be drug failures.

The resulting net book-to-bill ratio for the quarter was 1.21 and was 1.17 for the full year. Our target book-to-bill for fiscal year 2014 remains at 1.2 for the full year, bearing in mind normal quarterly fluctuations.

On the Strategic Partnership front, the model has proven to be successful. As a data point in this regard, 85% of client and non-client pharmaceutical executives that where interviewed in a recent survey said that they believe strategic partnerships have a positive impact on the client-CRO relationship. They identified the major beneficial impact of the partnership to be a reduction in the level of required client oversight, keeping a higher percentage of their costs variable, access to capabilities and expertise not found internally, improved global reach and accelerate time-to-market. Furthermore, 65% said that they believed that outsourcing would increase beyond current levels in the coming years. Overall, we are confident about renewals. We have a value-creation mindset from day one of the partnership, and as we build value over the duration of the partnership, the idea of renewal is not a surprise for either party.

Turning now to a couple of additional highlights of the fiscal year. We achieved a sharp reduction in DSO year-over-year. We succeeded in attaining DSO of 42 days at the end of the June quarter, down from 49 days in the June quarter of 2012. I'd like to thank our finance and operational teams for their hard work in realizing this goal. Our new target is to achieve DSO in the mid-30s.

The decline in DSO contributed to strong operating cash flow of $185 million for the full year. Free cash flow was $104 million in the fiscal year 2013 and our cash balance at the end of June totaled $276 million.

In another development, we entered into a note purchase agreement in late June with a select group of institutional investors for a private placement financing. PAREXEL has received gross proceeds of $100 million from the sale of the notes with a 7-year bullet maturity and a 3.11% coupon. Funding took place in late July. Our net debt position at the end of the year was $172 million, up $166 million from $6 million in June 2012.

The company's also made significant progress by returning value to our shareholders through a successfully completed stock buyback program, totaling nearly $200 million. We continued to evaluate our financial strategy on a regular basis.

Shifting now to our thoughts about the industry overall. The newest edition of the PAREXEL Pharmaceutical R&D Statistical Sourcebook was recently issued. In reviewing some of the highlights in the edition, I came away feeling more positive about the industry and the prospect for our clients. For example, the biopharma industry submitted applications for 35 new molecular entities to the FDA in calendar 2012, the most since 1998. We also observed that biotechnology-related projects comprised a higher share of the R&D pipeline, which now equates to 36% compared to 32% in 2010. We believe that this bodes well for the health of some of our small and midsized clients.

As we enter into our new fiscal year, I believe that we are well positioned to continue to deliver solid growth in revenue and earnings per share. Revenue growth drivers include anticipated increases in outsourcing penetration, our differentiated product offerings, the ability to leverage our thought leadership position to take additional market share and potential acquisition activity.

Profit drivers include a more normalized operating environment, improved resource management, process refinement and the achievement of further synergies amongst our businesses. I'm excited about fiscal year 2014 and remain confident in our ability to reap further benefits for our shareholders.

So at this point, I'd like to turn the call over to Jim, who will provide more detail on our financial results.

James F. Winschel

Thanks, Joe, and good morning, everyone. I'd like to start by making some additional comments regarding our 3 reporting segments beginning with CRS.

During the fourth quarter, CRS service revenue increased by 17.6% compared with the prior year quarter, driven by strength in all operating units. On a sequential basis, revenue increased slightly. Excluding the $2.4 million negative impact of foreign exchange, revenue would have been up 18.4% on a year-over-year basis. For full fiscal year, CRS revenue was up 25.5% compared with fiscal year 2012.

With respect to the September quarter, we expect revenue in CRS to be down slightly as a result of normal seasonality. CRS gross margin was 28.1% during the fourth quarter, up 3.6 points compared with the fourth quarter 1 year ago and up 0.2 of a point sequentially. The year-over-year improvement was primarily the result of increased productivity, a reduction in contract staff, lower hiring costs and the impact of other improvement initiatives. We expect CRS margins to continue to improve in the September quarter despite the impact of normal revenue seasonality. For the full year, CRS gross margin of 26.6% was down slightly, compared with fiscal year 2012. However, we have been trending in the right direction over the past 6 months.

In PCMS, quarterly service revenue was up 9.2% compared with the June quarter 1 year ago and up 7.3% sequentially. On a same-store basis, excluding $2.2 million in revenue from the HERON acquisition, revenue increased 4.8% year-over-year.

You may remember that in the fourth quarter of the prior year, we had an unusually strong revenue level because work on a couple of large projects have been accelerated into fiscal year 2012 at the request of 2 clients. The same-store revenue increase in the current quarter was driven by the consulting side of the business. And for the full fiscal year, PCMS revenue grew 21.2%.

For the fourth quarter, PCMS gross margin was 40.3%, down 1.6 points versus a year ago and up 0.4 of a point sequentially. The year-over-year decline was driven by a less favorable revenue mix and the impact of investments being made to drive future revenue growth. Looking forward, we expect PCMS revenue and margins to remain stable in the September quarter. Full year PCMS gross margin of 40.3% was down 1.3 points from a year ago, as a result of growth-related investment activity, as previously mentioned.

Quarterly service revenue in Perceptive Informatics increased 28.7% year-over-year in the quarter, and increased 6.4% on a sequential basis. Excluding the $10.5 million impact of Liquent, Perceptive revenue was up 8% year-over-year. For the full year, Perceptive service revenue grew by 19.8%. And excluding the $20.2 million impact of Liquent, revenue grew by 9.1%.

Perceptive's gross margin in the quarter was 45.8%, up 6.4 points, compared with the prior year and up 2.1 points sequentially. The improvement resulted primarily from the better revenue mix, including the impact of Liquent and substantial strength in Medical Imaging.

For the full fiscal year, Perceptive's gross margin at 43% was up 3.2 points. And looking forward to the September quarter, we expect a slight sequential decrease in Perceptive's service revenue and gross margin as a result of normal seasonality.

On an overall company basis, gross margin for the quarter was 32%, up 3.3 points from 1 year ago and up 0.6 of a point sequentially for the reasons previously mentioned. For the full fiscal year, gross margin at 30.4% was flat compared with last year, and looking ahead to the first quarter of fiscal year 2014, we expect gross margin to increase from Q4's level.

SG&A spending in the fourth quarter was 18.9% of revenue, up from 17.9% in the fourth quarter 1 year ago and down 0.2 of a point, sequentially. SG&A increased 24.2% on a year-over-year basis, driven by the acquisitions of Liquent and HERON, increased fixed and variable compensation expense and higher levels of other expenditures to support strong business growth. For the full fiscal year, SG&A was 18.1% of service revenue compared with 18.8% for fiscal year 2012. During the first quarter of fiscal year 2014, we expect SG&A as a percentage of service revenue to increase as a result of normal seasonality.

For the quarter, depreciation expense equated to 3.7% of service revenue, up from 3.4%, 1 year ago. And for the full year, depreciation was 3.6% of service revenue compared with 4.1% in fiscal year 2012.

Amortization expense was 0.9 of 1% of service revenue in the fourth quarter, compared with 0.6 of 1%, 1 year ago. And for the full year, amortization expense as a percent of service revenue was 0.6 of 1%, unchanged from 1 year ago, despite having completed 2 acquisitions during the year.

Operating margin in the fourth quarter was 8.6%, up 180 basis points from 1 year ago and up 0.4 of a point sequentially. For the full year, operating margin was 8% compared with 6.8%, 1 year ago, up 120 basis points.

Looking ahead, we expect operating margin to be in the 8.7% to 8.8% range in the September quarter and to be in the 9% to 9.4% range for fiscal year 2014. Operating margin would be up another 120 basis points from fiscal year 2013, assuming we achieve the midpoint of the full year range.

Other income totaled $400,000 in the quarter and consisted of foreign exchange gains, partly offset by net interest expense. For the full year, other expense was $3.3 million, consisting primarily of net interest expense, partly offset by foreign exchange gains.

In the first quarter of fiscal year 2014, we expect other expense to be in the $3 million range.

The company's fourth quarter adjusted tax rate of 27.6% compared with 24.7% in the fourth quarter of 2012. The year-over-year tax rate increase was a result of a less favorable mix of pretax profitability. For the full year, the adjusted tax rate was 25.9% compared with 24.8% in fiscal year 2012.

At this time, we are projecting a GAAP and adjusted tax rate of around 29% to 30% for the September quarter and for fiscal year 2014. There are several areas where we may have the opportunity to generate a lower rate, but timing is somewhat uncertain.

Net income for the quarter of $29 million was up 40.2% compared with net income of $20.7 million in the fourth quarter of fiscal year 2012. For the full fiscal year, net income increased by 51.9%. In the fourth quarter, diluted earnings per share came in at $0.50 versus $0.34 in the same period 1 year ago, an increase of 47.1%. And for the full fiscal year, EPS grew 53.6%.

Moving on to the balance sheet. Net receivables stood at $297 million at the end of June. Taking into account gross revenue of $648.9 million for the quarter, DSO was 42 days, a decrease of 7 days from the June quarter 1 year ago, but an increase of 6 days from the March quarter. The sequential increase was caused in part by the last 2 days of the quarter being nonbusiness days and timing of certain milestones.

With regards to cash flow, we started the quarter with $288.4 million in cash and marketable securities. During the quarter, cash flow generated by operations totaled $32.9 million. Other cash inflows included $47.9 million related to additional borrowings, $8.2 million in proceeds from the company's stock option and employee stock purchase programs and $1.1 million from other sources. Cash outflows, including $45.1 million related to purchases of the company's stock under our open market share repurchase program, $31 million for capital expenditures and $22.4 million for the acquisition of HERON.

Netting the inflows and outflows resulted in an overall decrease in cash and marketable securities of $8.5 million from the end of March, leaving us with a balance of $279.9 million for the end of June. Free cash flow totaled $104 million in fiscal year 2013 and is currently estimated to be in the range of $120 million to $135 million for fiscal year 2014. We expect capital expenditures in fiscal year 2014 to be in the $90 million to $95 million range and to be used primarily for hardware, software and capital costs related to expansion of facilities.

I'd now like to highlight some elements of the financial strategy, which we successfully executed during fiscal year 2013. In this regard, we have been effectively managing our borrowings as a part of our efforts to better leverage our balance sheet and reduce the company's cost of capital. These actions helped to fund PAREXEL's stock buyback program, complete the acquisitions of Liquent and HERON and enable us to appropriately invest in capital expenditures. The reduction in DSO helped to support the company's growth-related working capital needs.

Finally, and given that I will soon be passing the CFO baton to Ingo Bank, I would like to reiterate how proud I am to have played a part in PAREXEL's success over the past 13 years. We have had tremendous growth in revenue, backlog and market capitalization. But most importantly, we continue to be a trusted partner to our clients. I have enjoyed working with all of you in the investor and analyst communities over the years and in that connection, I am looking forward to taking on my new role and continuing to interact with all of you at conferences and on roadshows during the period leading up to my retirement.

Operator, at this point we are ready to begin the question-and-answer period.

Question-and-Answer Session

Operator

[Operator Instructions] Our first question comes from line of Tim Evans from Wells Fargo Securities.

Timothy C. Evans - Wells Fargo Securities, LLC, Research Division

Jim, congratulations on a nice swan song here. Can you talk a little bit about the investments you're making in PCMS? I know you're talking about positioning it for growth and you talked about the margin there being a little bit under pressure from those investments. Just curious, kind of what you see going forward.

James F. Winschel

Yes, sure, Tim, and thanks. We've been doing things like adding some additional experts in various areas. And when they first come on, they're not necessarily generating the same level of revenue they will after they've been here for a short time. And in addition to that, we are working on expanding our market presence in a number of parts of the world and I think Turkey was one of the areas that we had highlighted recently. But we've also done a lot of that kind of work over in the Asia Pacific region.

Timothy C. Evans - Wells Fargo Securities, LLC, Research Division

Okay, great. And maybe just a quick update on Phase I, as well as the logistics business.

Josef H. Von Rickenbach

Yes. Tim, this is Joe. So in Phase I, well first of all, I'd like to just make a general comment about Phase I, and that is as it relates to the company overall. Generally, we haven't had a lot of growth in recent times in Phase I. And with the overall growth of the company being so high, relatively speaking, the impact of Phase I, obviously, on Early Phase had shrunk further. And so it's a relatively small part of the overall mix of revenue at the current time. Having said that, it looks like the market has started to improve somewhat. We believe that Q2, the improved funding environment, especially for the small and emerging clients, there is a little bit more demand now from that segment and that's probably just enough to give us a little bit of hope for a better demand environment for both our [indiscernible]unit work and for inpatient work. And our proposal [ph] has actually been pretty strong, relatively speaking, always bearing in mind sort of the overall context and compared to prior quarters. As far as the logistics business is concerned, we are basically pleased with the performance of that business overall in the last year. Again, it's relatively small compared to everything else. But it's a promising kind of investment area for us right now, although nicely profitable and ensuring relatively high growth rates overall.

Operator

And our next question comes from the line of Douglas Tsao from Barclays.

Douglas D. Tsao - Barclays Capital, Research Division

Joe, just in terms of the uptick in demand that you just cited in the Phase I business in terms of proposals. Just curious, what type of clients are you seeing that? Is this from small biotechs? Is it from larger companies? Just curious, in terms of some of those underlying dynamics.

Josef H. Von Rickenbach

Okay, well, if we're focusing on that, I'd say there are basically 2 sources. One is that we have actually entered into partnerships in that area as well. So clearly, that is helping us. These partnerships can be with large pharma companies but also with smaller ones. But then, the small and emerging Biopharma client segment, what we call the SEBPCO segment, clearly has started to pick up a little bit. For a while after the financial crisis, funding for these companies was tough. And right now, I think we are starting to see a little bit of a result of the improved funding environment that has prevailed now over the last -- especially over the last year within all the number of IPOs that have happened and other funding that has flowed into the sector, that is starting to show up in Early Phase. A number of these clients, bear in mind, have pipelines that are relatively directed towards the early phases. And so it's really not a surprise that we see that.

Douglas D. Tsao - Barclays Capital, Research Division

Okay. And then in terms of the partnerships you just cited for the Phase I, are those generally part of your broader sort of enterprise clinical research Strategic Partnerships? And then also, in terms of the book-to-bill, it finished a little below your sort of long-term target of 1.2. Obviously, that's down from the level we saw in fiscal year 2012. Is it just a point of where your business is today and your mix for Strategic Partnerships there, that really, we should expect things not to sort of rebound back to the levels that we'd previously seen? And obviously, sort of understanding that like 1.8 from 2012 is an exception, but we've been seeing incomparably strong comps, sort of 1.3, being pretty consistent.

Josef H. Von Rickenbach

Okay, so just to finish out Early Phase, we have partnerships, corporate partnerships that include Early Phase, but we also have partnerships with clients that focus on Early Phase, not just to explain that. When it comes to the book-to-bill, I thought we had a pretty decent book-to-bill for the quarter, basically meeting our targets. Slightly below for the year but pretty much where we would expect the book-to-bill to be, long-term. Remember, we have been guiding to this now for a long time, many quarters. And partly, because our revenue level and the whole company is much larger. And so some of the new business successes that we have enjoyed, relatively speaking, meaning, relative to the revenue levels that we had 2 or 3 years ago, are probably not going to repeat. And so as the market and our performance normalizes, 1.2 is probably a more realistic expectation in terms of a net book-to-bill.

Operator

And our next question comes from the line of Robert Jones from Goldman Sachs.

Robert P. Jones - Goldman Sachs Group Inc., Research Division

Just a couple of -- and, Jim, just a couple of model questions actually. You talked about things and leverage on the gross profit line next year, with less hiring being one of the drivers. But as we look to the SG&A guidance for fiscal '14, it looks like it's calling for a good increase year-over-year, relative to what we saw in '13. I was just wondering if you could maybe elaborate on what's driving that.

James F. Winschel

Well, of course, we've gone through even a lot of changes during fiscal year '13. And if you remember in the first half of fiscal year 2013, we were actually seeing sequential declines in the gross margin within the CRS segment. And over the last 2 quarters, we started -- we've seen those numbers come back in the other direction. We're to a point where, with all of the huge number of employees that we had added, those people are becoming much more productive. We have plans to get the number of contractors, for example, in the organization, down to the targeted level by the end of December 2013. We have a number of systems that are going to come online, one in particular that's focused on helping us to better manage our resources. And you also have to remember that in calendar year 2012, with the Pfizer opportunity, not only were we winning new work from Pfizer to start from scratch, but we took in well over 100 projects that were transferred to us in midstream, which I think added to the degree of difficulty during that period. But these projects are now fully embedded into our company and things just tend to smooth out on that basis.

Robert P. Jones - Goldman Sachs Group Inc., Research Division

Okay, got it. So just a lot of moving pieces then, if we look at that 100-basis-point projected increase in SG&A as a percent of sales in '14 over '13 aside, it's not one major area that you'd point to?

James F. Winschel

No, not one major area.

Robert P. Jones - Goldman Sachs Group Inc., Research Division

And then the other one, just, Jim, if I could. Below the line, obviously there's some pretty big swing factors there, but can you maybe just help us think about how we should be modeling other income as we move forward? Quite a bit different, relative to our model, at least this quarter. And I guess along the same lines, you touched on this a bit in your prepared comments, but the tax rate guidance seems to be several hundred basis points above kind of where you'd been trending for '14. Just wondering if there's any specific drivers that you're focused on that you think will drive that tax rate up into fiscal '14?

James F. Winschel

All right. Well, let's talk first about the other income expense line. The first thing that we know is we sort of start off each quarter with a little over $2 million of interest expense. And what we've seen over the last 2 or 3 quarters have been that foreign exchange gains have offset that interest expense, and so we've seen a better number. In my model, I'm actually modeling probably $1 million of foreign exchange losses right now. And I think we have a great hedging program in place and it's working, but I'm being somewhat conservative in that regard. With respect to the tax rate, over the last several years, we were able to take advantage of the fact that we had valuation reserves on the books related to net operating losses, for example. And over that last 3-year period where our tax rates have been very low, you remember, we were down in the mid-teens at one point and then had got back into the mid-20s right now. And also, in that process, we're using large amounts of foreign tax credit that was available to us. As we go forward though, we're going to see some shifts there. And I think we have an ability to maybe have a sustainable tax rate that's somewhere in the 25% to 30% range. But there are certain changes that we're going to need to make now to the organization, as we've come to sort of the end of some of the valuation reserve reversal opportunities that we had. And for me, the timing of when will those things will get in place and when they'll take effect is uncertain. And I did, at the investor day, I was forecasting a tax rate of about 30%. I hedged it down to 29.5% in the go-forward, for fiscal year 2014. And that, on a whole-year basis, is worth about $0.01 per share.

Operator

And our next question comes from the line of Dave Windley from Jefferies.

David H. Windley - Jefferies LLC, Research Division

Joe, on the strategic deal landscape and outlook. For a couple of years, the company signed and was able to announce a really impressive list of strategic deals in fairly rapid succession. And I think you've talked about maybe half of the opportunities have been captured and still half of the opportunities are out there. I wondered if you could comment on the nature and pace of conversations that are ongoing with potential clients that haven't entered into strategic types of relationships. And is there -- should we expect the pace to be slower now because maybe the folks who are really amenable to that type of deal have already done it and the folks that remain are a little more cautious about entering into that type of relationship? Maybe you could give us some color on that.

Josef H. Von Rickenbach

Sure, Dave. Yes, so basically, you stated sort of our position well, and we are basically still observing that. So we have seen, if you want, the cohort of early adopters that have come into this model. And by the way, they tend to be more located in the U.S. and so pretty much that pace, if you want, is probably over. There have been some decisions this year also, and we're continuing to do well with that now. There is probably another -- fair number of companies that are looking at this model and are sort of thinking about it. But I think they also want to start to see some evidence from the early adopters that this actually works and that they are successful. And you may remember it in my comments, I actually quoted a survey that we conducted that basically went to the core of this question with clients. Is this working? Do they see the benefits? Are they happy with their decisions? And broadly speaking, I think the result of the survey endorsed our view that this is a mutually rewarding and probably better model going forward. And so I am fairly confident that eventually, this will show in the results of these companies also. Meaning, when we say strategic, it's not only strategic to us, it's also strategic to the client. And as a result, they will start to see benefits that are tangible as well in their productivity, in their costs. And I think, as that starts to become more evident, some of the folks who are currently on the sidelines but certainly interested and currently discussing the opportunities, will start to jump in as well.

David H. Windley - Jefferies LLC, Research Division

That's very helpful. So then, maybe slightly switching gears. Jim, on staffing, you mentioned to an earlier question reducing contractors might help out a little bit. I didn't hear if you said a number. I wondered if you provided a number, if you could. And then perhaps, I know that you're not -- I believe you're not including contractors in the full-time employee numbers that you put in the press release. And maybe you could help us to understand kind of the net change, how many new hires you had but how many of those replaced contractors in the quarter?

James F. Winschel

Well, we haven't actually quantified the number of contractors. What we did say today, however, is that we expect that by the end of December, that the contractor level would be at target. So the -- from that perspective, that's the best I can do for you right now. And in terms of overall headcount, I think it's important to remember that while our headcount, overall headcount went up about 400 people, net people this quarter, 140 of those came from the acquisition of HERON. And so we're sort of at a more normalized growth rate there. And I think we'll continue to see progress on the contractor front as we go forward as well. But those, then, will become full-time employees. So some portion of the 290-or-so, or 280 people that we added during the last quarter, were also replacing contractors.

David H. Windley - Jefferies LLC, Research Division

Okay. And is it possible, then, to quantify, if not quantify the number of contractors that you are reducing or has targeting to get to, is it possible to quantify, say, the basis points of impact to margin that getting to that target by the end of the year will deliver?

James F. Winschel

Well, so if you think about the guidance that we have provided today, we indicated that our operating margin was going to be in the 9% to 9.4% range. You take the midpoint there of 9.2% and look at where we finished fiscal year 2013 at 8%, that we've consistently been talking about it, 120-basis-point improvement in operating margins, and that's where we would expect to be. And a good chunk of that will come from gross margin improvement, including in the Clinical Research Services business.

Josef H. Von Rickenbach

But David, I just want to add to that. Don't forget, there is a whole list of initiatives in addition to the contracts that we are pursuing. And it's really important to bear in mind that we have diligence and a focus on them as well. And so, yes, we are talking about the contractors and obviously, Jim gave you some detail there. But these other initiatives are also very important and maybe long term, even more important, because they are really fundamentally taking and improving the business for the long run. Such as for instance, certain process refinements, which I mentioned, and other initiatives that we have going on.

Operator

Our next question comes from the line of Evan Stover from Robert W. Baird.

Evan A. Stover - Robert W. Baird & Co. Incorporated, Research Division

I wanted to parse out some of the changes in guidance from the investor day a couple of months ago. You obviously moved up the range a little bit. As I look at it, revenue up a little bit more from where you were, but not really materially so. So I look at it a little bit upside in tax rate, and maybe $0.01 or $0.02. So I'm just trying to get a better idea. Is it the productivity and contractor staffing utilization is kind of a little bit ahead of schedule and so maybe the guidance raise is half tax rate, half a little bit more confident in getting to the upper end of your up margin assumptions? If you could just provide a little bit more color there, that would be helpful.

James F. Winschel

Right. So, yes, we did take the revenue up $5 million at each end of the range, and so that accounts for some of the improvement here for sure. But in addition to that, I want to make sure that people heard what I said. We're indicating that the margin, for example, in the CRS segment, is going to, we believe, increase from the fourth quarter level to the first quarter level. And in the 13 years that I've been here, that's a sort of an unusual event. Usually, we have a seasonal decline there. So I think that's another great indication of the kind of improvements that we're making, and we're doing things operationally that are driving better productivity. And this is, other than the $0.01 on the tax rate line, is driving the increase, which, by the way, I mean, we were only a 1.5 months ago or 5 weeks ago or so that we had the investor day. So the signals, I think, are pretty good that we're giving here with respect to the improvement in margins in the CRS business.

Evan A. Stover - Robert W. Baird & Co. Incorporated, Research Division

All right, that's helpful. And kind of a small one. If I look at revenue from your largest client in the quarter, it looks like it ticked down about $12 million sequentially. I'm just trying to get a better handle if there was something in 3Q that was maybe driving that number to be a little bit higher. And we should think of it growing from the 4Q level? Or if there was just something seasonal in this quarter with that client. Any help there?

Josef H. Von Rickenbach

Yes, Evan, this is Joe. You're right, it did tick down a little bit from the prior quarter, and it probably is not going to come back up again. And I would expect that this may have to do with the transfer of studies that Jim mentioned before that are now working through the system. And we are now, basically moving into the next phase there, where -- which will behave more normally in the sense that new awards will start at the beginning, if you want, and are not come -- the instream studies that we had and that had a very rapid increase in revenue, are basically moving towards the maturity, as far as project completion is concerned.

Evan A. Stover - Robert W. Baird & Co. Incorporated, Research Division

All right. One final question. Capital deployment strategy. You're done with the share repurchase program. The $120 million to $130 million free cash flow guidance. I mean, I know there's potential for M&A, but if I look at what you've done recently, that won't account for all of it. What's the balance? Is it a mix? Is there more room for share repurchase potentially delevering a little bit? What are your thoughts there?

James F. Winschel

Well, we go through more or less, an ongoing review of our financial strategies, and you're correct that we should see a bit more, we think, a continuing trend to do more in the way of acquisitions. But there have been no other decisions made, for example, with respect to stock buyback at this time. And everybody on the phone will be the first to know when, if we change any of those decisions or make any new decisions.

Operator

And our next question comes from the line of Todd Van Fleet from First Analysis.

Todd Van Fleet - First Analysis Securities Corporation, Research Division

Wanted to dig into Perceptive a little bit to the extent you'll allow us. The -- where are we at about margin for that business these days? And how far are we from where you think the margin could get to?

Josef H. Von Rickenbach

Todd, this is Joe. Yes, so if we look at the performance of the Perceptive business in this past fiscal year that we've seen, again, in the course of the year, overall compared to the prior year, a fairly significant improvement in its operating margin performance. And we still expect that to continue into the new fiscal year. And of course, that will show itself also in the gross margin. And so generally, as a trend, we would expect a continuing upward trend in the gross margin. Maybe not every quarter, it may tick up and down a little bit, seasonality maybe a factor and so on. But the broad trend and outlook continue to be up for a variety of reasons, not the least of which is just scale, which has probably been an important reason why we have not been actually more profitable in the past. But we are clearly now entering the stage where we will be at scale, are at scale. And so that alone will drive better operating margin performance.

Todd Van Fleet - First Analysis Securities Corporation, Research Division

So Joe, are we 1,000 or are we 1,500 basis points away from ultimately where you think that business should be operating kind of year-over-year marginalized?

James F. Winschel

Yes, Todd, this is Jim. Our targets at this time, are to get that business up into the low 50s, as far as the gross margin is concerned. But it will be a steady march rather than -- we might have an occasional quarter where there's a nicer jump and maybe even -- it won't always be a, I guess, a straight line to the top. But as Joe said, the general trend will be for that business to improve its profitability.

Todd Van Fleet - First Analysis Securities Corporation, Research Division

Yes, and in addition to the gross margin improvement then, Jim, it will -- we'll presumably see, or you'll see leverage below the gross margin line as the business continues to scale?

James F. Winschel

Yes. And so I think that's the point that Joe made with regard to the scale of the business.

Operator

And our next question comes from the line of John Kreger from William Blair.

Roberto Fatta

This is Robbie Fatta in for John today. You guys mentioned earlier that the transactional bookings were pretty good this quarter. And at least according to our data, biotech funding was pretty strong this quarter. And you had mentioned that your small clients were doing pretty well. Historically, what is the tale on bookings trends after a couple of good quarters of biotech funding?

Josef H. Von Rickenbach

Robin (sic) [Robbie], you can't really look at it that way. I think it's driven more by fundamentals versus just kind of a chart being kind of a situation. So as of right now, I think, by the way, not surprisingly, we indicated, I think, 2 or 3 quarters ago that generally, the market feels a little better. People have a little bit more of a bounce in their step overall and feel better about investing in the sector. Don't forget, we have had a record number of approvals last year. But we also, and in addition, had a record number of new submissions. And obviously, many investors in the biopharma space into small companies, have had a long period where there has been little payback, tangible payback. But I think given that we have started to see this more now, I would expect that we might see a period, and that period could be relatively long, of improved fund flow. And by the way, you're right, we have observed the same thing, that fund flow in the sector was up again compared to the prior quarter. And year-to-date, it is also up from the prior year.

Roberto Fatta

Great, that's helpful. And then secondly, just on your M&A comments, what are your expectations for the areas to enter? Are there specific holes in your portfolio that you're looking to fill at this point?

Josef H. Von Rickenbach

Yes, so first of all, I'd say to that, that we're very pleased with the acquisitions that we have made. And are, so far in the most recent era of M&A at PAREXEL, both companies are doing well and are meeting our expectations in terms of integration and overall performance. I'd also say that generally the M&A environment is relatively good for a company like ours. And we have specific areas and conditions that we feel the companies need to meet in order to be attractive to us. Most importantly, they have to fit into our strategy. Once again, generally, we are targeting companies that are kind of more attractive from a strategic point of view, versus from a mass point of view. But having said that, we're also, to some extent, opportunistic. And if a great deal came our way, obviously, we'll look at it.

And so specifics could be in the technology area where, as you know, we've just made an acquisition with Liquent. There is more opportunity there. Specific expertise, very similar, let's say, to HERON. It could be another target. Jim mentioned geography before, that could be potentially a target. Although we feel our footprint is strong and pretty much covers the areas where we want to be, but there are still, also, a few opportunities. So that's just a little bit of an overview of where we're looking. But generally, deal flow is pretty good and high quality.

Operator

And our next question comes from the line of Greg Bolan from Sterne Agee.

Gregory T. Bolan - Sterne Agee & Leach Inc., Research Division

So, Jim, getting to the questions around kind of utilization within CRS of bill left to ease, where do you think you guys are at, at this point? Are you somewhere around 80% to 85%? Or maybe give us a little bit of color on where you think you are in terms of scale in the CRS business.

James F. Winschel

Well, if you sort of look at historically, where that business has been and where we're at right now, I think we believe we still have quite a bit of opportunity to get to improvements. And in our view, eventually, to get to back to the historical levels.

Gregory T. Bolan - Sterne Agee & Leach Inc., Research Division

Okay, that's helpful. And then one just clarification on Early Phase questions earlier. Is it fair to assume that Early Phase is around 3% of revenues at this point, Jim?

James F. Winschel

Well, we haven't -- have never broken out either the Phase I business or the Phase IV business within the organization. But what is pretty clear, it should be clear to everybody, of course, is that Phase III trials are the big trials, the multiple-year trials and everything. And so, a large amount of the work that we're doing there is certainly Phase II III work. But we have nicely sized and nicely growing Phase I and Phase IV businesses.

Gregory T. Bolan - Sterne Agee & Leach Inc., Research Division

Okay. And then just the last question. The swing in FX this quarter, just getting back to the questions around SG&A. What was the FX impact this quarter? Was it a headwind or tailwind to operating margin?

James F. Winschel

We had a tailwind with respect to operating income that was north of $3 million and more heavily located in the Asia Pacific region.

Operator

And that concludes our question-and-answer session today. I'd like to turn the conference back over to Mr. Von Rickenbach for concluding remarks.

Josef H. Von Rickenbach

Okay, thanks, Connie. And I'd like to thank everyone for your questions and your interest in PAREXEL. And we are looking forward to updating you on our next phone call. Bye-bye.

Operator

Ladies and gentlemen, thank you for your participation in today's conference. This does conclude the program and you may now disconnect. Everyone, have a good day.

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